Welcome to Regional Centre for Biotechnology

Dr. Avinash Bajaj

Associate Professor
E-mail: bajaj at rcb dot res dot in

PhD 2008, Indian Institute of Science
Postdoc at University of Massachusetts,USA

Research Team

Dr. Siddhi Gupta
Young Investigator
Email: [email protected]
Vedagopuram Sreekanth
Senior Research Fellow
[email protected]
Somanath Kundu
Senior Research Fellow
[email protected]
Kavita Yadav
Senior Research Fellow
[email protected]
Mr. Sandeep Kumar
Senior Research Fellow
[email protected]
Mr. Nihal Medatwal
Senior Research Fellow
[email protected]
Mr. Sanjay Pal
Senior Research Fellow
[email protected]
Ms. Ruchi Tripathi
Junior Research fellow
[email protected]
Animesh Kar
Junior Research Fellow
[email protected]
Priyanka Verma
Junior Research Fellow
[email protected]
Deepak Kumar Mishra
Junior Research fellow
Mohammad Asad
Junior Research fellow
Mayla Vamshikrishna
Junior Research fellow

Publications

Yavvari PS, Pal S, Kumar S, Kar A, Awasthi A,Naaz A, Srivastava A, Bajaj A (2017) An Injectable, Self-healing Chimeric Catechol-Fe(III) Hydrogel for Localized Combination Cancer Therapy ACS Biomaterials Sci. & Eng (In Press)
Sreekanth V, Medatwal N, Kumar S, Pal S, Malyla V, Kar A, Bhargava P, Naaz A, Kumar N, Sengupta S, Bajaj A (2017) Tethering of Chemotherapeutic Drug/Imaging Agent to Bile Acid-Phospholipid Increases the Efficacy and Bioavailability with Reduced Hepatotoxicity. Bioconjugate Chem. (In Press).
Kundu S, Bansal S, Muthukumarasamy KM, Sachidanandan C, Motiani r, Bajaj A (2017) Deciphering the Role of Hydrophobic and Hydrophilic Bile Acids in Angiogenesis using in vitro and in vivo Model Systems. MedChemComm (In Press).
Kidwai S, Park C, Mawatwal S, Tiwari P, Jung MG., Gossain T, Kumar P, Alland D, Kumar S, Bajaj A, Hwang Y, Song CS, Dhiman R, Lee Y, Singh? R? (2017) The dual mechanism of action of 5-Nitro-1,10-Phenanthroline against Mycobacterium tuberculosis. Antimicrob Agents Chemother. ??[Epub ahead of print]
Hussain T, Saha D, Purohit G, Kar A, Mukherjee AK , Sharma S, Sengupta S, Dhapola P, Maji B, Vedagopuram S, Horikoshi NT, Horikoshi N, Pandita RK, Bhattacharya S , Bajaj A, Riou JF, TK Pandita, Chowdhury S (2017) Transcription regulation of CDKN1A (p21/CIP1/WAF1) by TRF2 is epigenetically controlled through the REST repressor complex.Sci Rep. 7:11541
Sreekanth? ?V?,? Medatwal? ?N?, Pal S?, Kumar S?, Sengupta S?, Bajaj A (2017) Molecular Self-Assembly of Bile Acid-Phospholipids Controls the Delivery of Doxorubicin and Mice Survivability? Mol. Pharm (Accepted)
Yavvari P, Gupta S, Arora D,Nandicoori V, Srivastava A, Bajaj A (2017) Clathrin Independent Killing of Intracellular Mycobacteria and Biofilm Disruptions using Synthetic Antimicrobial Polymers, Biomacromolecules, Accepted

Rana S, Elci SG, Mout R, Singla AK, Yazdani M, Bender M, Bajaj A, Saha K, Bunz UHF, Jirik FR, and Rotello VM, (2016) Ratiometric Array of Conjugated Polymers-Fluorescent Protein Provides a Robust Mammalian Cell Sensor. J. Am. Chem. Soc.138:4522
Gupta S, Singh M, Reddy AM, Yavvari PS, Srivastava A, and Bajaj A. (2016) Interactions governing the entrapment of anticancer drugs by low molecular weight hydrogelator for drug delivery applications. RSC Adv. 6:19751
Kundu S, Kumar S, Bajaj A. (2015) Cross-talk between bile acids and gastrointestinal tract for progression and development of cancer and its therapeutic implications. IUBMB Life 67:514.
S. Kumar, P. Bhargava, V. Sreekanth, and A. Bajaj, (2015) Design, Synthesis, and Physico-Chemical Interactions of Bile Acid Derived Dimeric Phospholipid Amphiphiles with Model Membranes. J. Colloid Interface Sci 448:398.
K. Yadav, P. Bhargava, S. Bansal, M. Singh, S. Gupta, G. Sandhu, S. Kumar, V. Sreekanth, and A. Bajaj, (2015) Nature of the Charged Head Group Dictates the Anticancer Potential of Lithocholic Acid-Tamoxifen Conjugates For Breast Cancer Therapy, MedChemComm (Advance Article).
A. Sharma, S. Bansal, A. A. Pohane, A. Bajaj, V. Jain, A. Srivastava. (2015) Cell-Penetrating Synthetic Antimicrobial Polypeptides (SAMPs) Exhibiting Potent and Selective Killing of Mycobacterium by Targeting its DNA. Chem Eur J 21:3540
M Singh, S Bansal, S Kundu, P Bhargava, A Singh, R Motiani, R Shyam, V Sreekanth, S Sengupta, A Bajaj. (2015) Synthesis, Structure-Activity Relationship, and Mechanistic Investigation of Lithocholic Acid Amphiphiles for Colon Cancer Therapy. Med Chem Commun 6:192.
Singh K, Verma V, Yadav K, Sreekanth V, Kumar D, Bajaj A, Kumar V. (2014) Design, Regioselective Synthesis and Cytotoxic Evaluation of 2-Aminoimidazole-quinoline Hybrids Against Cancer and Primary Endothelial Cells. Eur J Med Chem 87:150.
Bansal S, Singh M, Kidwai S, Bhargava P, Singh A, Sreekanth V, Kundu S, Singh R, Bajaj A. (2014) Bile Acid Amphiphiles with Tunable Head Groups as Highly Selective Non-hemolytic Antitubercular Agents. Med Chem Commun 5:1761.
Singh M, Kundu S, Reddy A, Sreekanth V, Motiani R K, Sengupta S, Srivastava A, Bajaj A. (2014) Injectable small molecule hydrogel for localized and sustained in vivo delivery of Doxorubicin. Nanoscale 6:12849.
Singh M, Bajaj A. (2014) Unraveling the Impact of Hydroxylation on Interactions of Bile Acid Cationic Lipids with Model Membranes by In-depth Calorimetry Studies. Phys Chem Chem Phys 16:19266.
Bhargava P, Singh M, Sreekanth V, Bajaj A. (2014) Nature of the Charged Head Group Determines the Fusogenic Potential and Membrane Properties of Lithocholic Acid Phospholipids. J Phys Chem B 118:9341.
Vedagopuram S, Bajaj A. (2013) Number of Free Hydroxyl Groups on Bile Acid Phospholipids Determines the Fluidity and Hydration of Model Membranes. J Phys Chem B 117:12135.
Sharma S, Kundu S, Reddy AM, Bajaj A, Srivastava A. (2013) Design and Engineering of Stable and Biocompatible Disulfide-cross-linked Nanocomplexes of Polyamide Polyelectrolytes for Cytosolic Delivery of Entrapped Peptide Cargo. Macromol Biosci 13:927.
Vedagapuram S, Bansal S, Motiani R, Kundu S, Muppu SK, Datta T, Panjamurthy K, Sengupta S, Bajaj A. (2013) Design, Synthesis and Mechanistic Investigations of Bile Acid-Tamoxifen Conjugates for Breast Cancer Therapy. Bioconjugate Chem 24:1468.
Singh M, Singh A, Kundu S, Bansal S, Bajaj A. (2013) Interactions of Bile Acid based Facial Amphiphiles with Membranes Influences their Anticancer Activities for Colon Cancer. Biophys Biochim Acta Biomembr 1828:1926.
Vedagopuram S, Bajaj A. (2013) Fluorescece (Fluidity/hydration) and Calorimetric Studies of Interactions of Bile Acid Tamoxifen Conjugates with Model Membranes. J Phys Chem B 117:2123.
Rana S, Singla AK, Bajaj A, Elci SG, Miranda OR, Mout R, Yan B, Jirik FR, Rotello VM. (2012) Array-Based Sensing of Metastatic Cells and Tissues Using Nanoparticle-Fluorescent Protein Conjugates. ACS Nano 6:8233.
Rana S, Bajaj A, Mout R, Rotello VM. (2011) Monolayer Coated Gold Nanoparticles for Delivery Applications. Adv Drug Del Rev 64:200.
Saha K, Bajaj A, Duncan B, Rotello VM. (2011) Beauty is Skin Deep: A Surface Monolayer Perspective on Nanoparticle Interactions with Cells and Biomacromolecules. Small 7:1903.
Biswas J, Bajaj A, Bhattacharya S. (2011) Membranes of Cationic Gemini Lipids based on Cholesterol with Hydroxyl Headgroups and their Interactions with DNA and Phospholipid. J Phys Chem B 115:478.
Subramani C, Saha K, Creran B, Bajaj A, Moyano DF, Wang H, Rotello VM. (2012) Cell Alignment Using Patterned Biocompatible Gold Nanoparticle Templates. Small 8:1209.
Subramani C, Cengiz N, Saha K, Gevrek TN, Yu X, Jeong Y, Bajaj A, Sanyal A, Rotello VM. (2011) Direct Fabrication of Functional and Biofunctional Nanostructures Through Reactive Imprinting. Adv Mater 23:3165.
Subramani C,Bajaj A, Miranda OR, Rotello VM. (2010) Biocompatible Charged and Uncharged Surfaces Using Nanoparticle Films. Adv Mater 22:5420.
Bajaj A, Rana S, Miranda OR, Kim IB, Phillips RL, Jerry DJ, Bunz UH, Rotello VM. (2010) Cell Surface-based Differentiation of Cell Types and Cancer States Using a Gold Nanoparticle-GFP Based Sensing Array. Chem Sci 1:134.
Bajaj A, Miranda OR, Phillips R, Kim IB, Jerry DJ, Bunz UH, Rotello VM. (2010) Array Based Sensing of Mammalian Cell Types Using Conjugated Polymers. J Am Chem Soc 132:1018.
Bajaj A, Miranda OR, Kim IB, Phillips RL, Jerry DJ, Bunz UH, Rotello VM. (2009) Detection and differentiation of normal, cancerous, and metastatic cells using nanoparticle-polymer sensor arrays. Proc Nat Acad Sci USA 106:10912.
Bajaj A, Samanta B, Yan HH, Jerry DJ, Rotello VM. (2009) Stability, Toxicity and Differential Cellular Uptake of Protein Passivated-Fe3O4 Nanoparticles. J Mater Chem19:6328.
Krebs MD, Erb RM, Yellen BB, Samanta B, Bajaj A, Rotello VM, Alsberg E. (2009) Formation of Ordered Cellular Structures in Suspension via Label-Free Negative Magnetophoresis. Nano Lett. 9:1812.
Bhattacharya S, Bajaj, A. (2009) Recent Advances in Gene Delivery Through Molecular Design of Cationic Lipids. Chem Commun 6432.
Bajaj A, Kondaiah P, Bhattacharya S. (2008) Gene Transfection Efficacies of Novel Cationic Gemini Lipids Possessing Aromatic Backbone and Oxyethylene Spacers. Biomacromolecules 9: 991.
Bajaj A, Mishra S, Kondaiah P, Bhattacharya S. (2008) Effect of the headgroup variation on the gene transfer properties of cholesterol based cationic lipids possessing ether linkage. Biochim Biophys Acta: Biomembr 1778:1222.
Bajaj A, Kondaiah P, Bhattacharya S. (2008) 'Effect of The Nature of Spacer on Gene Transfer Efficacies of Thiocholesterol Derived Gemini Lipids in Different Cell Lines: A Structure-Activity Investigation. J Med Chem 51:2533.
Bajaj A, Paul B, Indi SS, Kondaiah P, Bhattacharya S. (2008) Structure-Activity Investigation on The Gene Transfection Efficiencies of Cariolipin Mimicking Gemini Lipid Analogues. Bioconjugate Chem 19:1283.
Bhattacharya S, Bajaj, A. (2008) Fluorescence and Thermotropic Studies of The Interactions of PEI-Cholesterol Based Lipopolymers With Dipalmitoylphosphatidylcholine (DPPC) Membranes. Biochim Biophys. Acta: Biomembr 1778:2225.
Bajaj A, Kondaiah P, Bhattacharya S. (2008) Synthesis and Gene Transfection Efficacies of PEI−Cholesterol-Based Lipopolymers. Bioconjugate Chem 19:1640.
Bhattacharya S, Bajaj A. (2007) Membrane Forming Properties of Pseudoglyceryl Backbone Based Gemini Lipids Possessing Oxyethylene Spacers. J Phys Chem B 111:2463.
Bajaj A., Kondaiah P, Bhattacharya S. (2007) Synthesis and Gene Transfection Properties of Novel Serum Compatible Cholesterol Based Gemini Lipids Possessing Oxyethylene Spacers. Bioconjugate Chem 18:1537.
Bajaj A, Kondaiah P, Bhattacharya S. (2007) Design, Synthesis and In Vitro Gene Transfection Properties of Novel Cholesterol Based Gemini Lipids and Their Serum Compatibility: A structure-Activity Investigation. J Med Chem 50:2432.
Bhattacharya S, Bajaj A. (2007) Thermotropic and Hydration studies of Gemini Pseudoglyceryl Lipids Possessing Polymethylene Spacers. Langmuir 23:8988.
Bajaj A, Paul B, Indi SS, Kondaiah P, Bhattacharya S. (2007) Effect of the Hydrocarbon Chain Lengths and Spacer Lengths on Gene Transfection Efficacies of Gemini Lipids Based on Aromatic Backbone. Bioconjugate Chem 18:2144.
Bhattacharya S, Bajaj A. (2007) Membrane-Forming Properties of Gemini Lipids Possessing Aromatic Backbone between the Hydrocarbon Chains and the Cationic Headgroup. J Phys Chem B 111:13511.
Paul B, Bajaj A, Indi SS, Bhattacharya S. (2006) Synthesis of Novel Dimeric Lipids Based on an Aromatic Backbone Between the Hydrocarbon Chains and Head Groups. Tetrahedron Lett 47:8401.
Bhattacharya S, Bajaj A. (2005) Recent Trends in Lipid Molecular Design. Curr Opin Chem Biol 9:647.

Dr. Avinash Bajaj
Assistant Professor
Regional Centre for Biotechnology
NCR Biotech Science Cluster
3rd Milestone, Faridabad-Gurgaon Expressway
P.O. Box No. 3, Faridabad - 121 001
Haryana (NCR Delhi), India

Dr. Avinash Bajaj

Research Theme

Achievements

Research Team

Publications

Contact