Visiting Scientist
E-mail: samba.eswaran at rcb dot res dot in
(i) The discovery of the new molecule "Viswamayene" (named after the late Prof M A Viswamitra, IISC, Bangalore and a famous X-ray crystallographer). The formation of these unusual molecules involves 'long-lived' transients and nitrene-carbene conversion. Subsequently, the life span of one such transient was measured by ultra-fast spectroscopy to be 700 picoseconds
(ii) Homo and hetero-bifunctional crosslinkers based on 'long lived' transients are known to yield to more efficient intermolecular crosslinking of peptides/proteins. Thus crosslinking of lysozyme has been successfully carried out by us. The new technique of chemical crosslinking-mass spectrometry-bioinformatics is very useful for such studies. The distance constraints between the interacting amino acids in proteins can thus be determined. This is expected to play a major tool in proteomics, systems/ structural biology and the origin of diseases. Crosslinking of a-Crystallin, the transparent protein of the human eye lens is being studied. This in turn leads to Cataractogenesis, i.e. the origin of Cataract. We are especially looking for collaborative work on studies on protein complexes.
(iii) Such 'Long Lived' transients covalently bind to Nanocarbon materials (fullerene C60, SWCNT/ MWCNT, Graphene) very efficiently making them easily soluble in common organic solvents. This paves the way for using such adducts for preparing Solar Cells and for use in Organic Electronics. Cytoxicity studies on the above adducts is also being carried out to employ these for nano-drug delivery.
Patents
Dr. S. V. Eswaran
Emeritus Scientist-CSIR & Emeritus Professor-AcSIR
Regional Centre for Biotechnology
NCR Biotech Science Cluster
3rd Milestone, Faridabad-Gurgaon Expressway
P.O. Box No. 3, Faridabad - 121 001
Haryana (NCR Delhi), India
Phone: 0129 - 2848801
E-mail: samba.eswaran at rcb dot res dot in
Phone: 91 129-2848888